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Measurement Data

Measurement data is orthogonal data associated with Land Omics Data, such as compound/drug screening and RNAi data. User can add measurement data to create views and query the land omics data.

Import Measurement Data

In this tutorial, we are using a cell line land data as one example since it has drug screening data. User can add measurement data in Manage | Measurement | Add Measurement Data:

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The measurement data source file should have columns for Sample ID matching Land samples, measurement label column containing compound/screening names, and one or more measurement columns. Example of IC50 table below:

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User can browse the measurement data using Manage | Measurement | Manage Measurement Data:

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User can also add measurement meta data in Manage | Measurement | Add Measurement Meta Data

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These meta data will be attached to each compound when browsing them in Manage Measurement Data window.

Search/Visualize Measurement Data

Once measurement data is imported, the measurement labels (such as compound names) are searchable in the search box:

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There are boxplot and heatmap views for this compound:

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Measurement Data Query

Measurement data can also be used to query Land Omic Data in custom query in any Sample tab:

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User can categorize the measurement data into categories, such as sensitive and resistant, using numeric break points or directly labeling. Here we categorize the drug IC50 values for Nutlin-3a by:

  • <3: sensitive
  • Between 3 and 6: middle

  • 6 Resistant

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The custom query results can be used as a filter and profile column in views for Omics data.

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